Kaohsiung Journal of Medical Sciences
Volume 23, Issue 10 , Pages 491-497, October 2007

Association of Apolipoprotein E Polymorphism with Ischemic Stroke Subtypes in Taiwan

  • Chiou-Lian Lai

      Affiliations

    • Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Neurology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Ching-Kuan Liu

      Affiliations

    • Department of Neurology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Ruey-Tay Lin

      Affiliations

    • Department of Neurology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Chih-Ta Tai

      Affiliations

    • Department of Neurology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Chih-Ta Tai, Department of Neurology, Kaohsiung Medical University Hospital, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan

Received 24 July 2006; accepted 5 February 2007.

The aim of this study was to clarify whether the apolipoprotein E gene (APOE) is related to ischemic stroke subtypes in Taiwan's Chinese population. Using the classification of Cerebrovascular Diseases III, 143 patients with lacunar infarction, 114 patients with atherothrombotic infarction, and 112 healthy controls were enrolled. APOE genotype was determined using polymerase chain reaction. Regarding the distribution of APOE genotypes, the frequency of ɛ3/ɛ4 genotypes in lacunar patients was significantly different from that in control subjects, by logistic regression, using ɛ3/ɛ3 as a reference group. There was no significant difference between atherothrombotic patients and the control group in the distribution of APOE genotypes or alleles. The present finding suggests that there is a probable association between ɛ3/ɛ4 genotype and lacunar infarcts, but not atherothrombotic infarcts. This indicates that genetic factors may play a role, at least partially, in lacunar infarction in Taiwan's Chinese population.

Key Words:  apolipoprotein E , ischemic stroke , Taiwan

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PII: S1607-551X(08)70006-8

doi:10.1016/S1607-551X(08)70006-8

Kaohsiung Journal of Medical Sciences
Volume 23, Issue 10 , Pages 491-497, October 2007

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