Kaohsiung Journal of Medical Sciences
Volume 23, Issue 9 , Pages 442-446, September 2007

Diffusion-weighted Magnetic Resonance Imaging of the Liver in Hepatitis B Patients with Child-Pugh A Cirrhosis

  • Feng-O Hsu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Yen-Yu Chiou

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Chiao-Yun Chen

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Gin-Chung Liu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Hui-Chen Chu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Hui-Cheng Liu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Hui-Min Chu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Jui-Sheng Hsu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Jui-Sheng Hsu, Department of Medical Imaging, Kaohsiung Municipal Hsiao-Kang Hospital, 482 Shan-Ming Road, Kaohsiung 812, Taiwan

Received 16 March 2007; accepted 2 May 2007.

The purpose of this study was to test the hypothesis that cirrhotic change of liver in hepatitis B patients observed in Child-Pugh classification based on clinical assessment would be reflected in the apparent diffusion coefficient (ADC) values calculated from diffusion-weighted magnetic resonance (MR) imaging. Twenty-seven patients with hepatitis B Child-Pugh class A cirrhosis and 10 control subjects were referred for measurement values of the liver on a 3.0-T MR unit. The results revealed that ADCs were significantly lower in hepatitis B patients with Child-Pugh class A compared with control subjects (p<0.01). In conclusion, our preliminary study showed that hepatitis B patients with Child-Pugh class A had reduced ADC values in liver vis-a-vis normal subjects.

Key Words:  diffusion-weighted imaging , hepatitis B , liver , magnetic resonance imaging

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PII: S1607-551X(08)70051-2

doi:10.1016/S1607-551X(08)70051-2

Kaohsiung Journal of Medical Sciences
Volume 23, Issue 9 , Pages 442-446, September 2007

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