Kaohsiung Journal of Medical Sciences
Volume 23, Issue 9 , Pages 442-446, September 2007

Diffusion-weighted Magnetic Resonance Imaging of the Liver in Hepatitis B Patients with Child-Pugh A Cirrhosis

  • Feng-O Hsu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Yen-Yu Chiou

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Chiao-Yun Chen

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Gin-Chung Liu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Hui-Chen Chu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Hui-Cheng Liu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Hui-Min Chu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Jui-Sheng Hsu

      Affiliations

    • Department of Medical Imaging, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Jui-Sheng Hsu, Department of Medical Imaging, Kaohsiung Municipal Hsiao-Kang Hospital, 482 Shan-Ming Road, Kaohsiung 812, Taiwan

Received 16 March 2007; accepted 2 May 2007.

Article Outline

The purpose of this study was to test the hypothesis that cirrhotic change of liver in hepatitis B patients observed in Child-Pugh classification based on clinical assessment would be reflected in the apparent diffusion coefficient (ADC) values calculated from diffusion-weighted magnetic resonance (MR) imaging. Twenty-seven patients with hepatitis B Child-Pugh class A cirrhosis and 10 control subjects were referred for measurement values of the liver on a 3.0-T MR unit. The results revealed that ADCs were significantly lower in hepatitis B patients with Child-Pugh class A compared with control subjects (p<0.01). In conclusion, our preliminary study showed that hepatitis B patients with Child-Pugh class A had reduced ADC values in liver vis-a-vis normal subjects.

Key Words:  diffusion-weighted imaging , hepatitis B , liver , magnetic resonance imaging

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Lin X , Robinson NJ , Thursz M , et al.   Chronic hepatitis B virus infection in the Asia-Pacific region and Africa: review of disease progression . J Gastroenterol Hepatol . 2005;20:833–843
  2. Chen CH , Yang PM , Huang GT , et al.   Estimation of seroprevalence of hepatitis B virus and hepatitis C virus in Taiwan from a large-scale survey of free hepatitis screening participants . J Formos Med Assoc . 2007;106:148–155
  3. Chen DS . Hepatitis B virus infection, its sequelae, and prevention in Taiwan . In:  Okuda K ,  Ishak KG editor. Neoplasms of the Liver . Tokyo: Springer-Verlag; 1987;p. 71–80
  4. Tobkes AI , Nord HJ . Liver biopsy: review of methodology and complications . Dig Dis . 1995;13:267–274
  5. Kasper DL , Fauci AS , Longo DL , et al.   Harrison's Principles of Internal Medicine . 16th edition. New York: McGraw-Hill; 2005;
  6. Le Bihan D . Diffusion/perfusion MR imaging of the brain: from structure to function . Radiology . 1990;177:328–329
  7. Le Bihan D , Breton E , Lallemand D , et al.   Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging . Radiology . 1988;168:497–505
  8. Le Bihan D , Turner R , Douek P , et al.   Diffusion MR imaging: clinical applications . AJR Am J Roentgenol . 1992;159:591–599
  9. Naganawa S , Kawai H , Fukatsu H , et al.   Diffusionweighted imaging of the liver: technical challenges and prospects for the future . Magn Reson Med Sci . 2005;4:175–186
  10. Boulanger Y , Amara M , Lepanto L , et al.   Diffusionweighted MR imaging of the liver of hepatitis C patients . NMR Biomed . 2003;16:132–136
  11. Koinuma M , Ohashi I , Hanafusa K , et al.   Apparent diffusion coefficient measurements with diffusion-weighted magnetic resonance imaging for evaluation of hepatic fibrosis . J Magn Reson Imaging . 2005;22:80–85
  12. Taouli B , Vilgrain V , Dumont E , et al.   Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients . Radiology . 2003;226:71–78
  13. Taouli B , Martin AJ , Qayyum A , et al.   Parallel imaging and diffusion tensor imaging for diffusion-weighted MRI of the liver: preliminary experience in healthy volunteers . AJR Am J Roentgenol . 2004;183:677–680
  14. Amano Y , Kumazaki T , Ishihara M . Single-shot diffusionweighted echo-planar imaging of normal and cirrhotic livers using a phased-array multicoil . Acta Radiol . 1998;39:440–442
  15. Wang K , Wang PJ , Zhao ZH , et al.   Functional MRI in chronic liver disease of hepatitis B patients . Zhonghua Gan Zang Bing Za Zhi . 2006;14:590–596
  16. Colagrande S , Carbone SF , Carusi LM , et al.   Magnetic resonance diffusion-weighted imaging: extraneurological applications . Radiol Med (Torino) . 2006;111:392–419

PII: S1607-551X(08)70051-2

doi:10.1016/S1607-551X(08)70051-2

Kaohsiung Journal of Medical Sciences
Volume 23, Issue 9 , Pages 442-446, September 2007

Article Tools