The-1131T > C Polymorphism in the Apolipoprotein A5 Gene is Related to Hypertriglyceridemia in Taiwanese Aborigines

Huang, Meng-Chuan; Wang, Tsu-Nai; Wang, Huan-Sen; Sung, Yi-Ching; Ko, Ying-Chin; Chiang, Hung-Che

doi:10.1016/S1607-551X(08)70114-1

Next »Kaohsiung Journal of Medical Sciences
Volume 24, Issue 4 , Pages 171-179, April 2008

The-1131T > C Polymorphism in the Apolipoprotein A5 Gene is Related to Hypertriglyceridemia in Taiwanese Aborigines

Meng-Chuan Huang
- Department of Public Health, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
- Faculty of Respiratory Care, Kaohsiung Medical University, Kaohsiung, Taiwan
- Department of Nutrition, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Tsu-Nai Wang
- Faculty of Public Health, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Huan-Sen Wang
- Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Yi-Ching Sung
- Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Ying-Chin Ko
- Department of Public Health, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
- Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Kaohsiung, Taiwan
Hung-Che Chiang
- Department of Public Health, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
- Address correspondence and reprint requests to: Dr Hung-Che Chiang, Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1^st Road, Kaohsiung 807, Taiwan

Received 23 April 2007; accepted 29 October 2007.

The prevalence of hypertriglyceridemia, considered to be an independent risk factor for the development of cardiovascular disease, is high in Taiwanese aborigines. This study was undertaken to examine the effect of the -1131T > C polymorphism in the apolipoprotein A5 gene on serum triglyceride levels in female Taiwanese aborigines. This was a cross-sectional study, and a total of 316 unrelated female Taiwanese aborigines were genotyped at the -1131T > C polymorphism in apolipoprotein A5 using the polymerase chain reaction-restriction fragment length polymorphism method. Serum triglyceride ≥150 mg/dL was defined as the hypertriglyceridemia group and triglyceride < 150 mg/dL was considered to be the control group. The frequency of the minor C allele was significantly higher in the hypertriglyceridemia group (0.53) than in the control group (0.35) (p < 0.001). The frequency of this rare allele was comparable to that in Japanese and Han Chinese, but was higher than that in Caucasians. In a multiple logistic model adjusted for possible confounders, C allele-containing variants were independently associated with greater risks (CT genotype: OR = 3.28, 95% CI = 1.43–7.56; CC genotype: OR = 5.86, 95% CI = 2.15–15.99) of hyper-triglyceridemia than the TT genotype (p < 0.01), notably with the CC homozygote exhibiting the greatest risks. The genotype polymorphisms were also associated with serum triglyceride concentrations in a linear fashion (for trend, p < 0.05). Our results indicate that the -1131T > C polymorphism of the Apo A5 gene influences serum triglyceride levels in female Taiwanese aborigines, and that differences exist in the frequency of the C allele among people of various ethnicities.