Kaohsiung Journal of Medical Sciences
Volume 24, Issue 5 , Pages 274-277, May 2008

Primary Urethral Plasmacytoma: a Case Report and Literature Review

  • Ozgur Gokce

      Affiliations

    • Department of Urology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    • ,
  • Omer Acar

      Affiliations

    • Department of Urology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Omer Acar, Department of Urology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    • ,
  • Murat Tunc

      Affiliations

    • Department of Urology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    • ,
  • Isin Kilicaslan

      Affiliations

    • Department of Pathology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    • ,
  • Tarik Esen

      Affiliations

    • Department of Urology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    • ,
  • Faruk Ozcan

      Affiliations

    • Department of Urology, Faculty of Medicine, Istanbul University, Istanbul, Turkey

Received 4 September 2007; accepted 2 November 2007.

Article Outline

Plasmacytomas of the urethra are extremely rare neoplasias; they may occur as isolated tumors or concomitantly with generalized multiple myeloma. Herein, we describe the clinical presentation and characteristics of a patient with primary plasmacytoma of the urethra. A 51-year-old man presented with terminal hematuria and a palpable penile mass. Magnetic resonance urethrography revealed a 3-cm long stenotic segment along which the urethral mucosa was found to be irregular. On urethroscopy, papillary mucosal projections extending to the presphincteric area were noted. Lesions were found to be composed primarily of neoplastic plasma cells capable of producing mainly lambda light chain. Upon diagnosis, the patient received external beam radiation therapy targeting the pelvic region. The lesion diminished in size progressively during the treatment course. He was disease-free after 6 months. Although it is a relatively rare disease, primary urethral plasmacystoma should be considered in the differential diagnosis of urethral tumors and radiation therapy should be an integral part of the treatment strategy.

Key Words:  extramedullary plasmacytoma , multiple myeloma , radiotherapy , urethra

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References 

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PII: S1607-551X(08)70153-0

doi:10.1016/S1607-551X(08)70153-0

Kaohsiung Journal of Medical Sciences
Volume 24, Issue 5 , Pages 274-277, May 2008

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