Kaohsiung Journal of Medical Sciences
Volume 24, Issue 10 , Pages 548-552, October 2008

Cytologic Diagnosis of Primary Effusion Lymphoma in an HIV-Negative Patient

  • Yue-Chiu Su

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Taipei, Taiwan
    • ,
  • Chee-Yin Chai

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Taipei, Taiwan
    • Department of Pathology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taipei, Taiwan
    • ,
  • Shih-Sung Chuang

      Affiliations

    • Department of Pathology, Chi-Mei Medical Center, Tainan, Taipei, Taiwan
    • Department of Pathology, Taipei Medical University, Taipei, Taiwan
    • ,
  • Yung-Liang Liao

      Affiliations

    • Department of Pathology, Chi-Mei Medical Center, Tainan, Taipei, Taiwan
    • ,
  • Wan-Yi Kang

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Taipei, Taiwan
    • Department of Pathology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taipei, Taiwan
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Wan-Yi Kang, Department of Pathology, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan

Received 3 March 2008; accepted 26 March 2008.

Article Outline

Primary effusion lymphoma (PEL) is an unusual and rare type of non-Hodgkin's lymphoma characterized by lymphomatous effusion of pleural, pericardial or peritoneal cavities without lymphadenopathy or organomegaly. It is associated with human herpes virus-8 (HHV-8) and occurs most often in immunodeficient patients. We present a case of PEL in a 69-year-old male presenting with pleural effusion and ascites. Fluid aspiration showed a monomorphic population of atypical lymphoid cells, which were medium- to large-sized, with mono- or binucleated hyper-chromatic nuclei and a small to moderate amount of basophilic cytoplasm containing cytoplasmic vesicles. Immunohistochemically, the lymphoid cells expressed CD138 and multiple myeloma oncogene 1, were positive for HHV-8, and were monoclonal for immunoglobulin heavy chain gene rearrangement. They were negative for Epstein-Barr virus by in situ hybridization. Unfortunately, the patient died during the first course of chemotherapy with cyclophosphamide, vincristine and prednisone.

Key Words:  human herpes virus-8 , human immunodeficiency virus , primary effusion lymphoma

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PII: S1607-551X(09)70015-4

doi:10.1016/S1607-551X(09)70015-4

Kaohsiung Journal of Medical Sciences
Volume 24, Issue 10 , Pages 548-552, October 2008

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