Kaohsiung Journal of Medical Sciences
Volume 24, Issue 11 , Pages 591-597 , November 2008

Carcinoma Showing Thymus-Like Differentiation (CASTLE) of Thyroid: A Case Report and Literature Review

  • Leong-Perng Chan

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Feng-Yu Chiang

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Feng-Yu Chiang, Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan
    • ,
  • Ka-Wo Lee

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Wen-Rei Kuo

      Affiliations

    • Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Received 2 May 2008 ,Accepted 31 July 2008.

References 

  1. Miyauchi A , Kuma K , Matsuzuka F , et al.   Intrathyroidal epithelial thymoma: an entity distinct from squamous cell carcinoma of the thyroid . World J Surg . 1985;9:128–135
  2. Ahuja AT , Chan ES , Allen PW , et al.   Carcinoma showing thymic-like differentiation (CASTLE tumor) . AJNR Am J Neuroradiol . 1998;19:1225–1228
  3. Luo CM , Hsueh C , Chen TM . Extrathyroid carcinoma showing thymus-like differentiation (CASTLE) tumor— a new case report and review of literature . Head Neck . 2005;27:927–933
  4. Chan JK , Rosai J . Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept . Hum Pathol . 1991;22:349–367
  5. Mizukami Y , Kurumaya H , Yamada T , et al.   Thymic carcinoma involving the thyroid gland: report of two cases . Hum Pathol . 1995;26:576–579
  6. Kusada N , Hara Y , Kobayashi S , et al.   A case of aggressive carcinoma showing thymus-like differentiation with distant metastases . Thyroid . 2005;15:1383–1388
  7. Yoneda K , Matsui O , Kobayashi T , et al.   CT and MRI findings of carcinoma showing thymus-like differentiation . Radiat Med . 2005;23:451–455
  8. Roka S , Kornek G , Schuller J , et al.   Carcinoma showing thymic-like elements—a rare malignancy of the thyroid gland . Br J Surg . 2004;91:142–145
  9. Miyauchi A , Ishikawa H , Maeda M . Intrathyroidal epithelial thymoma: a report of 6 cases with immunohistochemical and ultrastructural studies . Endocr Surg . 1989;6:289–295
  10. Kakudo K , Mori I , Tamaoki N , et al.   Carcinoma of possible thymic origin presenting as a thyroid mass: a new subgroup of squamous cell carcinoma of the thyroid . J Surg Oncol . 1988;38:187–192
  11. Damiani S , Filotico M , Eusebi V . Carcinoma of the thyroid showing thymoma-like features . Virchows Arch A Pathol Anat Histopathol . 1991;418:463–466
  12. Dorfman DM , Shahsafaei A , Miyauchi A . Intrathyroidal epithelial thymoma (ITET)/carcinoma showing thymuslike differentiation (CASTLE) exhibits CD5 immunoreactivity: new evidence for thymic differentiation . Histopathology . 1998;32:104–109
  13. Bacha EA , Chapelier AR , Macchiarini P , et al.   Surgery for invasive primary mediastinal tumors . Ann Thorac Surg . 1998;66:234–239

PII: S1607-551X(09)70020-8

doi: 10.1016/S1607-551X(09)70020-8

Kaohsiung Journal of Medical Sciences
Volume 24, Issue 11 , Pages 591-597 , November 2008

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