Kaohsiung Journal of Medical Sciences
Volume 25, Issue 4 , Pages 212-216, April 2009

Ischemic Stroke in Williams-Beuren Syndrome: A Case Report

  • Wei-Der Lee

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital;, Kaohsiung, Taiwan
    • ,
  • Jui-Jen Hsu

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital;, Kaohsiung, Taiwan
    • ,
  • Feng-Chen Huang

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital;, Kaohsiung, Taiwan
    • ,
  • Mei-Chyn Chao

      Affiliations

    • College of Medicine, Kaohsiung, Taiwan
    • Division of Genetics, Endocrinology and Metabolism, Department of Pediatrics, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Division of Cytogenetics, Department of Laboratory Medicine, Kaohsiung Medical University Hospital;, Kaohsiung, Taiwan
    • ,
  • Yu-Li Chang

      Affiliations

    • Division of Cytogenetics, Department of Laboratory Medicine, Kaohsiung Medical University Hospital;, Kaohsiung, Taiwan
    • ,
  • Mao-Hsiung Huang

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital;, Kaohsiung, Taiwan
    • College of Medicine, Kaohsiung, Taiwan
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Mao-Hsiung Huang, Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan

Received 19 December 2008; accepted 14 January 2009.

Article Outline

A 15-year-old girl was admitted because of an acute onset of facial palsy and right hemiparesis. The patient had a history of moderate mental retardation and developmental delay. On admission, her vital signs were stable, except for high blood pressure. Magnetic resonance imaging demonstrated an infarct involving the left internal capsule and putamen. Because of the patient's young age, an extensive stroke survey was performed. Williams-Beuren syndrome was finally confirmed by fluorescent in situ hybridization. Compared with the previously reported cases, no evidence of cerebral arterial stenosis or cardiac abnormalities was found by noninvasive imaging techniques. Because Williams-Beuren syndrome is a complex, multiple congenital anomaly syndrome with prominent cardiovascular features, regular assessment and antihypertensive treatment are necessary to minimize the lifelong cardiovascular risk in patients with this syndrome.

Key Words:  cardiovascular abnormalities , ischemic stroke , mental retardation , urinary incontinence , Williams-Beuren syndrome

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PII: S1607-551X(09)70063-4

doi:10.1016/S1607-551X(09)70063-4

Kaohsiung Journal of Medical Sciences
Volume 25, Issue 4 , Pages 212-216, April 2009

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