Kaohsiung Journal of Medical Sciences
Volume 22, Issue 7 , Pages 357-362, July 2006

Gitelman Syndrome: Report of Three Cases and Literature Review

  • Ya-Ting Lee

      Affiliations

    • Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan
    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • I-Fan Wang

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Tsung-Hsien Lin

      Affiliations

    • Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Chia-Tsuan Huang

      Affiliations

    • Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Chia-Tsuan Huang, Department of Pediatrics, Kaohsiung Medical University Chung-Ho Memorial Hospital, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan

Received 28 September 2005; accepted 15 February 2006.

Gitelman syndrome (GS) is a rare autosomal recessive, inherited renal tubular disorder. Herein, we report three cases of GS, one sporadic case and two siblings. They have typical laboratory findings, including hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. All of them were treated with oral potassium and magnesium supplements. They received regular pediatric clinic follow-up to check electrolytes and monitor development. These three cases reminded us that doctors should be alert to unexplained hypokalemia, which is usually the initial presentation of GS.

Key Words:  Gitelman syndrome , hypokalemia , metabolic alkalosis

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PII: S1607-551X(09)70323-7

doi:10.1016/S1607-551X(09)70323-7

Kaohsiung Journal of Medical Sciences
Volume 22, Issue 7 , Pages 357-362, July 2006

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