Kaohsiung Journal of Medical Sciences
Volume 22, Issue 11 , Pages 590-594, November 2006

Primary Pulmonary Synovial Sarcoma: A Case Report

  • Hsin-Hung Chen

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Wan-Ting Huang

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Wan-Yi Kang

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Pathology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Hsuan-Ying Huang

      Affiliations

    • Department of Pathology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    • ,
  • Chee-Yin Chai

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Pathology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Chee-Yin Chai, Department of Pathology, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan

Received 9 March 2006; accepted 18 May 2006.

We report a rare case of primary synovial sarcoma of the lung. A 57-year-old man had a well-defined tumor in the right middle lobe seen on chest computed tomography, and underwent lobectomy. Grossly, the nonencapsulated tumor measured 4.5 cm in greatest diameter, with a solid and tan-white cut surface. Histologically, the tumor was mainly composed of a dense proliferation of spindle cells. Immunohistochemical studies were focally positive for epithelial membrane antigen, and diffusely positive for CD99 and Bcl-2. Cytokeratin, S-100 protein, desmin, smooth muscle actin, and CD34 were absent. SYT-SSX1 gene fusion transcript was detected by reverse transcription-polymerase chain reaction, which is diagnostic of primary synovial sarcoma of the lung. We also review the literature with regard to the clinicopathologic, immunohisto-chemical, and molecular studies of primary pulmonary synovial sarcoma.

Key Words:  pulmonary synovial sarcoma , synovial sarcoma , SYT-SSX fusion gene transcripts

No full text is available. To read the body of this article, please view the PDF online.

 

PII: S1607-551X(09)70358-4

doi:10.1016/S1607-551X(09)70358-4

Kaohsiung Journal of Medical Sciences
Volume 22, Issue 11 , Pages 590-594, November 2006

Article Tools