Kaohsiung Journal of Medical Sciences
Volume 25, Issue 12 , Pages 640-646, December 2009

Expression of Signal Transducer and Activator of Transcription 3 and Suppressor of Cytokine Signaling 3 in Urothelial Carcinoma

  • Wan-Ting Huang

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Sheau-Fang Yang

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Pathology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Chun-Chieh Wu

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Pathology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Wan-Tzu Chen

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Ya-Chun Huang

      Affiliations

    • Department of Pathology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Yue-Chiu Su

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Chee-Yin Chai

      Affiliations

    • Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Department of Pathology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Chee-Yin Chai, Department of Pathology, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan

Received 25 March 2009; accepted 5 May 2009.

In this study, we investigated the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) Tyr705 and suppressor of cytokine signaling 3 (SOCS3) in urothelial carcinoma (UC). p-STAT3 (Tyr705) and SOCS3 were analyzed by immunohistochemistry using tissue microarray and Western blotting. Our results showed that p-STAT3 (Tyr705) was frequently detected in high-grade and infiltrating UC. However, there was no difference in p-STAT3 (Tyr705) staining between UC of the upper and lower urinary tracts. In addition, there was no significant correlation between expression of SOCS3 and histological differentiation and invasiveness of UC. These findings suggest that overexpression of p-STAT3 (Tyr705) occurs in UC, and that pathways other than SOCS3 may contribute to its activation in this cancer.

Key Words:  immunohistochemical staining , p-STAT3 , SOCS3 , tissue microarray , urothelial carcinoma

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PII: S1607-551X(09)70569-8

doi:10.1016/S1607-551X(09)70569-8

Kaohsiung Journal of Medical Sciences
Volume 25, Issue 12 , Pages 640-646, December 2009

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