Kaohsiung Journal of Medical Sciences
Volume 26, Issue 4 , Pages 217-221, April 2010

Neurofibroma in the Left Mandible: A Case Report

  • Qian Tao

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint request to: Dr Qian Tao, Department of Oral and Maxillo- facial Surgery, Affiliated Hospital of Stomatology, Sun Yat-Sen University, Guangzhou 510055, Guangdong, China
    • ,
  • Yi Wang
    • ,
  • Chaoqun Zheng

Department of Oral and Maxillofacial Surgery, Guanghua School and Hospital of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, Guangdong, China

Received 4 March 2009; accepted 10 April 2009.

We report a rare case of isolated neurofibroma arising in the left mandible without family history of neurofibromatosis type 1. The tumor was histopathologically analyzed and an immunohistochemical panel comprising S-100 protein was performed. Vim, HMB45, and HHF35 were negative. The tumor cells were fusiform in shape, arranged in a plexiform manner, and grew actively. Features typical of neurofibroma, including an enlarged nerve fascicle composed of elongated nuclei and scant cytoplasmic cells, were identified. Our study suggest that neurofibroma can occur in the jaw as an isolated benign tumor in patients without other features of neurofibromatosis type 1.

Key Words:  diagnosis , mandible , neurofibroma

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PII: S1607-551X(10)70032-2

doi:10.1016/S1607-551X(10)70032-2

Kaohsiung Journal of Medical Sciences
Volume 26, Issue 4 , Pages 217-221, April 2010

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