Kaohsiung Journal of Medical Sciences
Volume 26, Issue 7 , Pages 373-376, July 2010

Toxoplasma IgG Expressed in a Patient With Rosai-Dorfman Disease

  • Hung-Ju Liao
    • ,
  • Ching-Wen Chiang

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr Ching-Wen Chiang, 83 Nan Chang Street, Lotung, Yilan 265, Taiwan

Department of Otolaryngology, Lo Tung Poh-Ai Hospital, Ilan, Taiwan

Received 16 September 2009; accepted 28 December 2009.

Article Outline

Rosai-Dorfman Disease (RDD) is a rare benign disease characterized by sinus histiocytosis with massive lymphadenopathy. RDD can be differentiated from other types of histiocytosis by immunochemical analysis, as RDD is positive for S100. Conversely, toxoplasmosis lymphadenitis is characterized by clusters of epithelioid histiocytes in lymphoid tissue, with mixed lymphocytic and immunoblastic cell populations. The serology data could help in diagnosing toxoplasmosis lymphadenitis, as the toxoplasma IgG should be positive. Here we present the rare case of a 73-year-old woman who presented with a left parotid mass and multiple neck lymphadenopathy that initially had been diagnosed as toxoplasmosis lymphadenitis from a positive result on serology examination, but was finally proven to be RDD based on immunochemical results. We also discuss the relationship between RDD and toxoplasmosis in this case.

Key Words:  parotid tumor , Rosai-Dorfman disease , toxoplasmosis lymphadenopathy

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References 

  1. Gaitonde S . Multifocal, extranodal sinus histiocytosis with massive lymphadenopathy: an overview . Arch Pathol Lab Med . 2007;131:1117–1121
  2. Montoya JG . Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis . J Infect Dis . 2002;185(Suppl 1):S73–S82
  3. Rosai J , Dorfman RF . Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinical entity . Arch Pathol . 1969;87:63–70
  4. Montoya JG , Remington JS . Management of Toxoplasma gondii infection during pregnancy . Clin Infect Dis . 2008;47:554–566
  5. Eapen M , Mathew CF , Aravindan KP . Evidence based criteria for the histopathological diagnosis of toxoplasmic lymphadenopathy . J Clin Pathol . 2005;58:1143–1146
  6. Luppi M , Barozzi P , Garber R , et al.   Expression of human herpesvirus-6 antigens in benign and malignant lymphoproliferative diseases . Am J Pathol . 1998;153:815–823
  7. Fu CH , Huang SF , Jung SM , et al.   Radiology quiz case 2. Extranodal Rosai-Dorfman disease involving the right orbit and nasal cavity . Arch Otolaryngol Head Neck Surg . 2009;135:317; 319.

PII: S1607-551X(10)70061-9

doi:10.1016/S1607-551X(10)70061-9

Kaohsiung Journal of Medical Sciences
Volume 26, Issue 7 , Pages 373-376, July 2010

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