Toxoplasma IgG Expressed in a Patient With Rosai-Dorfman Disease
Article Outline
Rosai-Dorfman Disease (RDD) is a rare benign disease characterized by sinus histiocytosis with massive lymphadenopathy. RDD can be differentiated from other types of histiocytosis by immunochemical analysis, as RDD is positive for S100. Conversely, toxoplasmosis lymphadenitis is characterized by clusters of epithelioid histiocytes in lymphoid tissue, with mixed lymphocytic and immunoblastic cell populations. The serology data could help in diagnosing toxoplasmosis lymphadenitis, as the toxoplasma IgG should be positive. Here we present the rare case of a 73-year-old woman who presented with a left parotid mass and multiple neck lymphadenopathy that initially had been diagnosed as toxoplasmosis lymphadenitis from a positive result on serology examination, but was finally proven to be RDD based on immunochemical results. We also discuss the relationship between RDD and toxoplasmosis in this case.
Key Words: parotid tumor , Rosai-Dorfman disease , toxoplasmosis lymphadenopathy
No full text is available. To read the body of this article, please view the PDF online.
References
- . Multifocal, extranodal sinus histiocytosis with massive lymphadenopathy: an overview . Arch Pathol Lab Med . 2007;131:1117–1121
- . Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis . J Infect Dis . 2002;185(Suppl 1):S73–S82
- . Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinical entity . Arch Pathol . 1969;87:63–70
- . Management of Toxoplasma gondii infection during pregnancy . Clin Infect Dis . 2008;47:554–566
- . Evidence based criteria for the histopathological diagnosis of toxoplasmic lymphadenopathy . J Clin Pathol . 2005;58:1143–1146
- Expression of human herpesvirus-6 antigens in benign and malignant lymphoproliferative diseases . Am J Pathol . 1998;153:815–823
- Radiology quiz case 2. Extranodal Rosai-Dorfman disease involving the right orbit and nasal cavity . Arch Otolaryngol Head Neck Surg . 2009;135:317; 319.
PII: S1607-551X(10)70061-9
doi:10.1016/S1607-551X(10)70061-9
© 2010 Elsevier. Published by Elsevier Inc. All rights reserved.
